Greg Lewbart


Hot Topic Article: The Effect of Temperature and Salinity on the Elimination of Enrofloxacin in the Manila Clam Ruditapes philippinarum

May 19, 2012

Tags: Zhi-Qiang Changa, Ai-Xin Gaoa, Jian Lia & Ping Liua. Journal of Aquatic Animal Health Volume 24, Issue 1, 2012

A group of Chinese scientists have published a bath immersion pharmacokinetics study of enrofloxacin in Manila clams.

The citation is listed above and the abstract follows:


The effect of temperature and salinity on the elimination of enrofloxacin (EF) in Manila clams Ruditapes philippinarum was investigated. The clams, cultured under different temperatures and salinities (16C and 30, 22C and 30, or 22C and 20), were exposed to EF at 5 ug/mL of water in a medicated bath. After a 24-h exposure, the concentration of EF in various tissues was measured by high-performance liquid chromatography and the elimination rate of EF in those tissues was investigated by regression analysis. After the treatment, the initial concentrations of EF among tissues were (in decreasing order) plasma > gill > visceral mass > foot > adductor muscle. In all tissues the elimination half-life (t 1/2) of EF in the clams cultured at 22C and 20 and 16C and 30 were markedly longer than in those cultured at 22C and 30, and the t 1/2 at 16C and 30 was slightly longer than that at 22C and 20. Slight differences were also observed in t 1/2 values among various tissues. These data indicate that both temperature and salinity had significant effects on the elimination of EF in the Manila clams and that lower temperature or salinity could result in slower elimination.

Selected Works

Science Writing
The Second Edition of Invertebrate Medicine was released in December, 2011. It has been substantially expanded from the first edition to reflect the tremendous growth of the pertinent literature and work that is being accomplished in the fields of invertebrate animal medicine, disease investigation, conservation, husbandry, and animal welfare. In 2012 it is being recognized with a Text and Academic Authors Association TEXTY award for excellence in the Life Sciences Category and first place in the Health Care Professionals (nonphysicians) category of the 2012 American Medical Writers Association Book Awards.
This book, edited by Karen L. Rosenthal, Neil A. Forbes, Frederic L. Frye, and Gregory A. Lewbart, utilizes approximately 400 clinical cases to describe and address many of the major medical and surgical conditions of exotic animal pets.
Invertebrate Medicine is the single most comprehensive resource available today on invertebrate animal medicine.
" will without doubt want to own this excellent collection of questions from fish veterinarians on both sides of the Atlantic...." --David Williams, The Veterinary Journal
Creative Non-Fiction
"This is a delightful book. The stories, each amazingly different, are told with warmth, humor and sensitivity. They are sometimes sad, always captivating. It is a book you can dip into on a journey or read before sleep at night. Buy it and give copies to your friends." Jane Goodall
....a darn good yarn.
--Ken Moore, Naples Daily News
...well-told and environmentally informative story about buried treasure and smuggling of exotic animals...
--Rod Cockshutt, The News & Observer